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Central diabetes insipidus

Central diabetes insipidus, also called neurogenic diabetes insipidus, is a type of diabetes insipidus due to a lack of vasopressin (ADH) production in the brain

Prevalence

1-9 / 100 000

3,310 - 29,790

US Estimated

5,135 - 46,215

Europe Estimated

Age of Onset

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ICD-10

E23.2

Inheritance

Autosomal dominant

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Autosomal recessive

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Mitochondrial/Multigenic

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X-linked dominant

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X-linked recessive

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5 Facts you should know

FACT

1

A type of diabetes insipidus due to a lack of vasopressin (ADH) production in the brain

FACT

2

Vasopressin acts to increase the volume of blood (intravascularly), and decrease the volume of urine produced

FACT

3

The major symptoms of include urinating polyuria, nocturia), and polydipsia

FACT

4

The only symptom that CDI has in common with diabetes mellitus is polyuria

FACT

5

Diagnosis is by water deprivation test showing failure to maximally concentrate urine

Central diabetes insipidus is also known as...

Central diabetes insipidus

Neurogenic diabetes insipidus; Neurohypophyseal diabetes insipidus; Pituitary diabetes insipidus, neurogenic diabetes insipidus

What’s your Rare IQ?

Which of these hormones is lacking in central diabetes insipidus?

Common signs & symptoms

Anorexia

Polydipsia

Extreme thirst

Failure to thrive

Weight faltering

Nocturia

Anxiety

Excessive, persistent worry and fear

Hyponatremia

Low blood sodium levels

Fever

Excessive daytime somnolence

More than typical sleepiness during day

Top Clinical Trials

TitleDescriptionPhasesStatusInterventionsMore Information
Effects of Intranasal Oxytocin in Patients With Central Diabetes InsipidusThis is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (4 IU and 24 IU) in 18-60-year-old men and women with central diabetes insipidus to evaluate the effect of oxytocin on anxiety, depression and socioemotional functioning.Phase 1Not yet recruitingDrug: Oxytocin nasal sprayLearn more
PB to Treat Hereditary Nephrogenic Diabetes Insipidus, ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium Administrationhe purpose of this research is to study the effectiveness and safety of the medication PB in slowing the frequent urination related to tolvaptan as long-term treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD), or frequent urination related to inherited nephrogenic diabetes insipidus as an inherited condition or as an acquired condition from prior treatment with lithium.Phase 2RecruitingDrug: PBLearn more

Top Treatments in Research

AgentClass/Mechanism of ActionDevelopment StatusCompanyClinical StudiesMore Information
Oxytocin nasal sprayThe two main actions of oxytocin in the body are contraction of the womb (uterus) during childbirth and lactation. Oxytocin stimulates the uterine muscles to contract and also increases production of prostaglandins, which increase the contractions further. Men with central diabetes insipidus (CDI) have reduced plasma oxytocin levels and increased psychopathology.Phase 1Elizabeth Austen Lawson|Massachusetts General HospitalLearn moreMore information