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Disease Profile
Tetraamelia with pulmonary hypoplasia
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Syndrome of tetraamelia with pulmonary hypoplasia; Absence of upper and lower limbs with pulmonary hypoplasia
Categories
Congenital and Genetic Diseases
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names |
Learn More:
HPO ID
|
|---|---|---|
| Percent of people who have these symptoms is not available through HPO | ||
| Abnormality of the diaphragm |
Diaphragm issues
Diaphragmatic defect
[ more ] |
0000775 |
| Absent external genitalia | 0000042 | |
| Adrenal gland agenesis | 0011743 | |
| Anal atresia |
Absent anus
|
0002023 |
| Asplenia |
Absent spleen
|
0001746 |
| 0000007 | ||
|
Clouding of the lens of the eye
Cloudy lens
[ more ] |
0000518 | |
| Choanal atresia |
Blockage of the rear opening of the nasal cavity
Obstruction of the rear opening of the nasal cavity
[ more ] |
0000453 |
|
Cleft roof of mouth
|
0000175 | |
| Cleft upper lip |
Harelip
|
0000204 |
| Gastroschisis | 0001543 | |
|
Too much cerebrospinal fluid in the brain
|
0000238 | |
| Hypoplasia of the fallopian tube |
Underdeveloped fallopian tube
|
0008697 |
| Hypoplastic pelvis | 0008839 | |
| Low-set ears |
Low set ears
Lowset ears
[ more ] |
0000369 |
|
Little lower jaw
Small jaw
Small lower jaw
[ more ] |
0000347 | |
| Microphthalmia |
Abnormally small eyeball
|
0000568 |
| Peripheral pulmonary vessel aplasia | 0005316 | |
| Pulmonary hypoplasia |
Small lung
Underdeveloped lung
[ more ] |
0002089 |
| Renal agenesis |
Absent kidney
Missing kidney
[ more ] |
0000104 |
| Single naris |
Mono nostril
One nostril
Single nostril
[ more ] |
0009932 |
| Single umbilical artery |
Only one artery in umbilical cord instead of two
|
0001195 |
| Tetraamelia | 0003057 | |
| Urethral atresia | 0000068 | |
| Vaginal atresia |
Abnormally closed or absent vagina
|
0000148 |
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Tetraamelia with pulmonary hypoplasia. Click on the link to view a sample search on this topic.