Rare Endocrinology News

Disease Profile

Peripartum cardiomyopathy

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

Adult

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ICD-10

O90.3

Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Other names (AKA)

Postpartum cardiomyopathy; Meadows' syndrome

Categories

Female Reproductive Diseases; Heart Diseases

Summary

The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.
orphanet

Orpha Number: 563

Definition
Peripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.

Visit the Orphanet disease page for more resources.

Symptoms

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Medical Terms Other Names
Learn More:
HPO ID
30%-79% of people have these symptoms
Abnormal T-wave
0005135
Congestive heart failure
Cardiac failure
Cardiac failures
Heart failure

[ more ]

0001635
Dilated cardiomyopathy
Stretched and thinned heart muscle
0001644
Elevated jugular venous pressure
0030848
Exertional dyspnea
0002875
Fatigue
Tired
Tiredness

[ more ]

0012378
Hypertension
0000822
Left ventricular hypertrophy
0001712
Orthopnea
0012764
Palpitations
Missed heart beat
Skipped heart beat

[ more ]

0001962
Pedal edema
Fluid accumulation in lower limbs
Lower leg swelling

[ more ]

0010741
Reduced ejection fraction
0012664
Sinus tachycardia
0011703
5%-29% of people have these symptoms
Abnormal atrioventricular valve morphology
0006705
Chest pain
0100749
Crackles
0030830
Heart murmur
Heart murmurs
0030148
Increased serum interferon-gamma level
0030356
Left atrial enlargement
0031295
Mitral regurgitation
0001653
Myocarditis
Inflammation of heart muscle
0012819
Paroxysmal dyspnea
0012763
Peripheral edema
0012398
Preeclampsia
0100602
Pulmonary arterial hypertension
Increased blood pressure in blood vessels of lungs
0002092
Right ventricular dilatation
0005133
Right ventricular failure
0001708
Thromboembolism
0001907
Ventricular tachycardia
0004756
1%-4% of people have these symptoms
Abdominal pain
Pain in stomach
Stomach pain

[ more ]

0002027
Abnormality of thyroid physiology
Abnormal thyroid function
0002926
Anemia
Low number of red blood cells or hemoglobin
0001903
Asthma
0002099
Autoimmunity
Autoimmune disease
Autoimmune disorder

[ more ]

0002960
Cardiogenic shock
0030149
Diabetes mellitus
0000819
Left bundle branch block
0011713
Obesity
Having too much body fat
0001513
Respiratory failure
0002878
Stroke-like episode
0002401

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.

In-Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Peripartum cardiomyopathy. Click on the link to view a sample search on this topic.